View source for 1ujy


==Solution structure of SH3 domain in Rac/Cdc42 guanine nucleotide exchange factor(GEF) 6==
<StructureSection load='1ujy' size='340' side='right'caption='[[1ujy]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ujy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UJY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ujy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujy OCA], [https://pdbe.org/1ujy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ujy RCSB], [https://www.ebi.ac.uk/pdbsum/1ujy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ujy ProSAT], [https://www.topsan.org/Proteins/RSGI/1ujy TOPSAN]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ARHG6_HUMAN ARHG6_HUMAN] Defects in ARHGEF6 are the cause of mental retardation X-linked type 46 (MRX46) [MIM:[https://omim.org/entry/300436 300436]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.<ref>PMID:11017088</ref> 
== Function ==
[https://www.uniprot.org/uniprot/ARHG6_HUMAN ARHG6_HUMAN] Acts as a RAC1 guanine nucleotide exchange factor (GEF).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uj/1ujy_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ujy ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Aoki M]]
[[Category: He F]]
[[Category: Hirota H]]
[[Category: Inoue M]]
[[Category: Kigawa T]]
[[Category: Kikuno R]]
[[Category: Kobayashi N]]
[[Category: Koshiba S]]
[[Category: Matsuda T]]
[[Category: Matsuo Y]]
[[Category: Muto Y]]
[[Category: Nagase T]]
[[Category: Nagayama M]]
[[Category: Ohara O]]
[[Category: Osanai T]]
[[Category: Seki E]]
[[Category: Shirouzu M]]
[[Category: Tanaka A]]
[[Category: Terada T]]
[[Category: Uda H]]
[[Category: Yabuki T]]
[[Category: Yokoyama S]]
[[Category: Yoshida M]]