View source for 2a2v


==The solution structure of Jingzhaotoxin-XI==
<StructureSection load='2a2v' size='340' side='right'caption='[[2a2v]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2a2v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chilobrachys_guangxiensis Chilobrachys guangxiensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A2V FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2v OCA], [https://pdbe.org/2a2v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a2v RCSB], [https://www.ebi.ac.uk/pdbsum/2a2v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a2v ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/JZ11A_CHIGU JZ11A_CHIGU] Inhibits voltage-gated potassium channels (Kv2.1/KCNB1 > Kv4.2/KCND2 > Kv4.1/KCND1). Also inhibits voltage-gated sodium channels of subtype Nav1.5/SCN5A (in cardiac myocytes). The toxin shifts activation towards more depolarized potentials and is suggested to bind to the extracellular S3-S4 loop of the channel. Shows no significant toxic symptoms when injected into mice and into cockroaches.<ref>PMID:17176080</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Chilobrachys guangxiensis]]
[[Category: Large Structures]]
[[Category: Liang SP]]
[[Category: Liao Z]]