View source for 2kyl


==Solution structure of MAST2-PDZ complexed with the C-terminus of PTEN==
<StructureSection load='2kyl' size='340' side='right'caption='[[2kyl]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2kyl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KYL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kyl OCA], [https://pdbe.org/2kyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kyl RCSB], [https://www.ebi.ac.uk/pdbsum/2kyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kyl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MAST2_HUMAN MAST2_HUMAN] Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity).[UniProtKB:Q60592]

==See Also==
*[[Microtubule-associated serine/threonine kinase|Microtubule-associated serine/threonine kinase]]
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cordier F]]
[[Category: Delepierre M]]
[[Category: Lafon M]]
[[Category: Simenel C]]
[[Category: Terrien E]]
[[Category: Wolff N]]