View source for 2l4x


==Solution Structure of apo-IscU(WT)==
<StructureSection load='2l4x' size='340' side='right'caption='[[2l4x]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2l4x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L4X FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l4x OCA], [https://pdbe.org/2l4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l4x RCSB], [https://www.ebi.ac.uk/pdbsum/2l4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l4x ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ISCU_ECOLI ISCU_ECOLI] A scaffold on which IscS assembles Fe-S clusters. Exists as 2 interconverting forms, a structured (S) and disordered (D) form. The D-state is the preferred substrate for IscS. Converts to the S-state when an Fe-S cluster is assembled, which helps it dissociate from IscS to transfer the Fe-S to an acceptor. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.<ref>PMID:11577100</ref> <ref>PMID:22203963</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Kim JH]]
[[Category: Markley JL]]
[[Category: Tonelli M]]