View source for 2lkx


==NMR structure of the homeodomain of Pitx2 in complex with a TAATCC DNA binding site==
<StructureSection load='2lkx' size='340' side='right'caption='[[2lkx]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lkx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1yz8 1yz8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LKX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkx OCA], [https://pdbe.org/2lkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lkx RCSB], [https://www.ebi.ac.uk/pdbsum/2lkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lkx ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/PITX2_HUMAN PITX2_HUMAN] Peters anomaly;Axenfeld anomaly;Rieger anomaly;Ring dermoid of cornea;Axenfeld-Rieger syndrome. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/PITX2_HUMAN PITX2_HUMAN] Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity).
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Baird-Titus JM]]
[[Category: Chaney BA]]
[[Category: Clark-Baldwin K]]
[[Category: Dave V]]
[[Category: Doerdelmann T]]
[[Category: Ma J]]