View source for 2mbf


==Solution structure of the forkhead domain of Brugia malayi DAF-16a==
<StructureSection load='2mbf' size='340' side='right'caption='[[2mbf]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mbf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brugia_malayi Brugia malayi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MBF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbf OCA], [https://pdbe.org/2mbf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mbf RCSB], [https://www.ebi.ac.uk/pdbsum/2mbf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mbf ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Brugia malayi is a parasitic nematode that causes lymphatic filariasis in humans. Here the solution structure of the forkhead DNA binding domain of Brugia malayi DAF-16a, a putative ortholog of Caenorhabditis elegans DAF-16, is reported. It is believed to be the first structure of a forkhead or winged helix domain from an invertebrate. C. elegans DAF-16 is involved in the insulin/IGF-I signaling pathway and helps control metabolism, longevity, and development. Conservation of sequence and structure with human FOXO proteins suggests that B. malayi DAF-16a is a member of the FOXO family of forkhead proteins. Proteins 2014. (c) 2014 Wiley Periodicals, Inc.

The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a.,Casper SK, Schoeller SJ, Zgoba DM, Phillips AJ, Morien TJ, Chaffee GR, Sackett PC, Peterson FC, Crossgrove K, Veldkamp CT Proteins. 2014 Oct 9. doi: 10.1002/prot.24701. PMID:25297652<ref>PMID:25297652</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2mbf" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Brugia malayi]]
[[Category: Large Structures]]
[[Category: Casper SK]]
[[Category: Peterson FC]]
[[Category: Schoeller SJ]]
[[Category: Veldkamp CT]]