View source for 2vai


==Solution structure of a B-DNA hairpin at high pressure==
<StructureSection load='2vai' size='340' side='right'caption='[[2vai]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2vai]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VAI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vai OCA], [https://pdbe.org/2vai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vai RCSB], [https://www.ebi.ac.uk/pdbsum/2vai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vai ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Study of the effects of pressure on macromolecular structure improves our understanding of the forces governing structure, provides details on the relevance of cavities and packing in structure, increases our understanding of hydration and provides a basis to understand the biology of high-pressure organisms. A study of DNA, in particular, helps us to understand how pressure can affect gene activity. Here we present the first high-resolution experimental study of B-DNA structure at high pressure, using NMR data acquired at pressures up to 200 MPa (2 kbar). The structure of DNA compresses very little, but is distorted so as to widen the minor groove, and to compress hydrogen bonds, with AT pairs compressing more than GC pairs. The minor groove changes are suggested to lead to a compression of the hydration water in the minor groove.

Structural change in a B-DNA helix with hydrostatic pressure.,Wilton DJ, Ghosh M, Chary KV, Akasaka K, Williamson MP Nucleic Acids Res. 2008 Jul;36(12):4032-7. Epub 2008 May 31. PMID:18515837<ref>PMID:18515837</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2vai" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Akasaka K]]
[[Category: Chary KVA]]
[[Category: Ghosh M]]
[[Category: Williamson MP]]
[[Category: Wilton DJ]]