View source for 31zn


==Structure of CDK11-cyclin L-SAP30BP in complex with IACS-054647==
<StructureSection load='31zn' size='340' side='right'caption='[[31zn]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[31zn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=31ZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=31ZN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1KC9:4-[8-[[(3~{S})-piperidin-3-yl]amino]imidazo[1,2-a]pyridin-6-yl]benzenecarbonitrile'>A1KC9</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=31zn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=31zn OCA], [https://pdbe.org/31zn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=31zn RCSB], [https://www.ebi.ac.uk/pdbsum/31zn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=31zn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/S30BP_HUMAN S30BP_HUMAN] Plays a role in transcriptional repression by promoting histone deacetylase activity, leading to deacetylation of histone H3 (PubMed:21221920). Acts as a regulator of pre-mRNA splicing by facilitating assembly of the cyclin-L-CDK11 cyclin-dependent protein kinase complex, thereby promoting phosphorylation of SF3B1 (PubMed:38059508). May be involved in the regulation of beta-2-microglobulin genes (By similarity).[UniProtKB:Q02614]<ref>PMID:21221920</ref> <ref>PMID:38059508</ref>   (Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC.<ref>PMID:21221920</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Greber BJ]]
[[Category: McGeoch AJS]]
[[Category: Sheltzer JM]]