View source for 32zb


==Cryo-EM structure of native, mature HERV-K hexameric capsomer==
<StructureSection load='32zb' size='340' side='right'caption='[[32zb]], [[Resolution|resolution]] 3.24&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[32zb]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_endogenous_retrovirus_K Human endogenous retrovirus K]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=32ZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=32ZB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.24&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=32zb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=32zb OCA], [https://pdbe.org/32zb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=32zb RCSB], [https://www.ebi.ac.uk/pdbsum/32zb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=32zb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GAK8_HUMAN GAK8_HUMAN] The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.
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</StructureSection>
[[Category: Human endogenous retrovirus K]]
[[Category: Large Structures]]
[[Category: Lyu C]]
[[Category: Shen Y]]
[[Category: Zhang P]]