View source for 3ara


==Discovery of Novel Uracil Derivatives as Potent Human dUTPase Inhibitors==
<StructureSection load='3ara' size='340' side='right'caption='[[3ara]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ara]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ARA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ARA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MKH:1-[3-({(2R)-2-[HYDROXY(DIPHENYL)METHYL]PYRROLIDIN-1-YL}SULFONYL)PROPYL]PYRIMIDINE-2,4(1H,3H)-DIONE'>MKH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ara FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ara OCA], [https://pdbe.org/3ara PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ara RCSB], [https://www.ebi.ac.uk/pdbsum/3ara PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ara ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DUT_HUMAN DUT_HUMAN] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.<ref>PMID:8805593</ref> 

==See Also==
*[[DUTPase 3D structures|DUTPase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chong KT]]
[[Category: Fukuoka M]]
[[Category: Miyahara S]]
[[Category: Miyakoshi H]]