View source for 3veh


==Structure of a M. tuberculosis salicylate synthase, MbtI, in complex with an inhibitor methylAMT==
<StructureSection load='3veh' size='340' side='right'caption='[[3veh]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3veh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VEH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VEH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0GA:3-{[(1Z)-1-CARBOXYPROP-1-EN-1-YL]OXY}-2-HYDROXYBENZOIC+ACID'>0GA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3veh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3veh OCA], [https://pdbe.org/3veh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3veh RCSB], [https://www.ebi.ac.uk/pdbsum/3veh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3veh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MBTI_MYCTU MBTI_MYCTU] Mediates the production of salicylate from chorismate via an isochorismate intermediate. Presents both isochorismate synthase and isochorismate-pyruvate lyase activities. Salycilate is the starter unit in the production of the virulence-conferring salicylate-based siderophore mycobactin.<ref>PMID:16923875</ref> 

==See Also==
*[[Isochorismate pyruvate lyase|Isochorismate pyruvate lyase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Baker EN]]
[[Category: Bulloch EM]]
[[Category: Chi G]]
[[Category: Johnston JM]]
[[Category: Lott JS]]
[[Category: Manos-Turvey A]]
[[Category: Payne RJ]]