View source for 3wah


==Crystal Structure of HasAp with Iron MesoporphyrinIX==
<StructureSection load='3wah' size='340' side='right'caption='[[3wah]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3wah]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WAH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.54&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MH0:MESOHEME'>MH0</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wah OCA], [https://pdbe.org/3wah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wah RCSB], [https://www.ebi.ac.uk/pdbsum/3wah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wah ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G3XD33_PSEAE G3XD33_PSEAE] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The heme acquisition system A protein secreted by Pseudomonas aeruginosa (HasAp ) can capture several synthetic metal complexes other than heme. The crystal structures of HasAp harboring synthetic metal complexes revealed only small perturbation of the overall HasAp structure. An inhibitory effect upon heme acquisition by HasAp bearing synthetic metal complexes was examined by monitoring the growth of Pseudomonas aeruginosa PAO1. HasAp bound to iron-phthalocyanine inhibits heme acquisition in the presence of heme-bound HasAp as an iron source.

Inhibition of Heme Uptake in Pseudomonas aeruginosa by its Hemophore (HasAp ) Bound to Synthetic Metal Complexes.,Shirataki C, Shoji O, Terada M, Ozaki S, Sugimoto H, Shiro Y, Watanabe Y Angew Chem Int Ed Engl. 2014 Mar 10;53(11):2862-6. doi: 10.1002/anie.201307889., Epub 2014 Feb 7. PMID:24604808<ref>PMID:24604808</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3wah" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Shirataki C]]
[[Category: Shiro Y]]
[[Category: Shoji O]]
[[Category: Sugimoto H]]
[[Category: Watanabe Y]]