View source for 4cpc


==Crystal structure of human synaptonemal complex protein SYCP3==
<StructureSection load='4cpc' size='340' side='right'caption='[[4cpc]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4cpc]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CPC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cpc OCA], [https://pdbe.org/4cpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cpc RCSB], [https://www.ebi.ac.uk/pdbsum/4cpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cpc ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SYCP3_HUMAN SYCP3_HUMAN] Male infertility with normal virilization due to meiosis defect. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/SYCP3_HUMAN SYCP3_HUMAN] Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity).<ref>PMID:14643120</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Davies OR]]
[[Category: Pellegrini L]]
[[Category: Syrjanen JL]]