View source for 4eot


==Crystal structure of the MafA homodimer bound to the consensus MARE==
<StructureSection load='4eot' size='340' side='right'caption='[[4eot]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4eot]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EOT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.855&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eot OCA], [https://pdbe.org/4eot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eot RCSB], [https://www.ebi.ac.uk/pdbsum/4eot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eot ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MAFA_HUMAN MAFA_HUMAN] Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.<ref>PMID:12011435</ref> <ref>PMID:12368292</ref> <ref>PMID:15665000</ref> <ref>PMID:15993959</ref> <ref>PMID:18042454</ref> <ref>PMID:19143053</ref> 

==See Also==
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Guanga G]]
[[Category: Lu X]]
[[Category: Rose RB]]
[[Category: Wan C]]