| Structural highlights
Function
MAFA_HUMAN Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.[1] [2] [3] [4] [5] [6]
See Also
References
- ↑ Olbrot M, Rud J, Moss LG, Sharma A. Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6737-42. PMID:12011435 doi:https://dx.doi.org/10.1073/pnas.102168499
- ↑ Kataoka K, Han SI, Shioda S, Hirai M, Nishizawa M, Handa H. MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. J Biol Chem. 2002 Dec 20;277(51):49903-10. Epub 2002 Oct 3. PMID:12368292 doi:https://dx.doi.org/10.1074/jbc.M206796200
- ↑ Zhao L, Guo M, Matsuoka TA, Hagman DK, Parazzoli SD, Poitout V, Stein R. The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription. J Biol Chem. 2005 Mar 25;280(12):11887-94. Epub 2005 Jan 20. PMID:15665000 doi:https://dx.doi.org/M409475200
- ↑ Aramata S, Han SI, Yasuda K, Kataoka K. Synergistic activation of the insulin gene promoter by the beta-cell enriched transcription factors MafA, Beta2, and Pdx1. Biochim Biophys Acta. 2005 Jul 25;1730(1):41-6. PMID:15993959 doi:https://dx.doi.org/10.1016/j.bbaexp.2005.05.009
- ↑ Rocques N, Abou Zeid N, Sii-Felice K, Lecoin L, Felder-Schmittbuhl MP, Eychene A, Pouponnot C. GSK-3-mediated phosphorylation enhances Maf-transforming activity. Mol Cell. 2007 Nov 30;28(4):584-97. PMID:18042454 doi:https://dx.doi.org/S1097-2765(07)00742-3
- ↑ Eychene A, Rocques N, Pouponnot C. A new MAFia in cancer. Nat Rev Cancer. 2008 Sep;8(9):683-93. PMID:19143053 doi:10.1038/nrc2460
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