View source for 4gqj


==Complex of a binuclear Ruthenium compound D,D-([mu-(11,11')-bi(dppz)-(1,10-phenanthroline)4-Ru2]4+) bound to d(CGTACG)==
<StructureSection load='4gqj' size='340' side='right'caption='[[4gqj]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4gqj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GQJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.951&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RR2:(MU-11,11-BIDIPYRIDO[3,2-A 2,3-C]PHENAZINE-1KAPPA~2~N~4~,N~5~ 2KAPPA~2~N~4~,N~5~)[TETRAKIS(1,10-PHENANTHROLINE-KAPPA~2~N~1~,N~10~)]DIRUTHENIUM'>RR2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqj OCA], [https://pdbe.org/4gqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gqj RCSB], [https://www.ebi.ac.uk/pdbsum/4gqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gqj ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of the Delta,Delta enantiomer of the binuclear "light-switch" ruthenium complex [mu-(11,11'-bidppz)(1,10-phenanthroline)4 Ru2 ](4+) bound to the oligonucleotide d(CGTACG) shows that one dppz moiety of the dumbbell-like compound inserts into the DNA stack through the extrusion of an AT base pair. The second dppz moiety recruits a neighboring DNA molecule, and the complex thus cross-links two adjacent duplexes by bridging their major grooves.

Thread insertion of a bis(dipyridophenazine) diruthenium complex into the DNA double helix by the extrusion of AT base pairs and cross-linking of DNA duplexes.,Boer DR, Wu L, Lincoln P, Coll M Angew Chem Int Ed Engl. 2014 Feb 10;53(7):1949-52. doi: 10.1002/anie.201308070., Epub 2014 Jan 21. PMID:24449275<ref>PMID:24449275</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4gqj" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Boer DR]]
[[Category: Coll M]]