View source for 4joi


==Crystal structure of the human telomeric Stn1-Ten1 complex==
<StructureSection load='4joi' size='340' side='right'caption='[[4joi]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4joi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JOI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JOI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4joi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4joi OCA], [https://pdbe.org/4joi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4joi RCSB], [https://www.ebi.ac.uk/pdbsum/4joi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4joi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/STN1_HUMAN STN1_HUMAN] Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.<ref>PMID:19854130</ref> <ref>PMID:19648609</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bryan C]]
[[Category: Harkisheimer M]]
[[Category: Rice C]]
[[Category: Schultz D]]
[[Category: Skordalakes E]]