View source for 4l9d


==Crystal structure of the PKD1 domain from Vibrio cholerae metalloprotease PrtV==
<StructureSection load='4l9d' size='340' side='right'caption='[[4l9d]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4l9d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_M66-2 Vibrio cholerae M66-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L9D FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l9d OCA], [https://pdbe.org/4l9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l9d RCSB], [https://www.ebi.ac.uk/pdbsum/4l9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l9d ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PRTV_VIBCM PRTV_VIBCM] Metalloprotease that exhibits a cytotoxic effect leading to cell death. In host tissues, it could play a role in pathogenesis by modulating the stability of the extracellular matrix components such as fibronectin and fibrinogen. Also able to cleave plasminogen.[UniProtKB:Q9KMU6]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Vibrio cholerae M66-2]]
[[Category: Edwin A]]
[[Category: Sauer-Eriksson AE]]
[[Category: Stier G]]