View source for 4n09


==Structure of Trypanosoma brucei brucei adenosine kinase in complex with adenosine and AMPPNP==
<StructureSection load='4n09' size='340' side='right'caption='[[4n09]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4n09]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei_TREU927 Trypanosoma brucei brucei TREU927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N09 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n09 OCA], [https://pdbe.org/4n09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n09 RCSB], [https://www.ebi.ac.uk/pdbsum/4n09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n09 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Trypanosoma brucei is a single-cellular parasite of the genus Kinetoplastida and is the causative agent of African sleeping sickness in humans. Adenosine kinase is a key enzyme in the purine-salvage pathway, phosphorylating adenosine to AMP, and also activates cytotoxic analogues such as cordycepin and Ara-A by their phosphorylation. The structures of T. brucei brucei adenosine kinase (TbAK) in its unliganded open conformation and complexed with adenosine and ADP in the closed conformation are both reported to 2.6 A resolution. The structures give insight into the binding mode of the substrates and the conformational change induced upon substrate binding. This information can be used to guide the improvement of cytotoxic substrate analogues as potential antitrypanosomal drugs.

Structures of adenosine kinase from Trypanosoma brucei brucei.,Timm J, Gonzalez-Pacanowska D, Wilson KS Acta Crystallogr F Struct Biol Commun. 2014 Jan;70(Pt 1):34-9. doi:, 10.1107/S2053230X13033621. Epub 2013 Dec 24. PMID:24419613<ref>PMID:24419613</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4n09" style="background-color:#fffaf0;"></div>

==See Also==
*[[Adenosine kinase 3D structures|Adenosine kinase 3D structures]]
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Trypanosoma brucei brucei TREU927]]
[[Category: Gonzalez-Pacanowska D]]
[[Category: Timm J]]
[[Category: Wilson KS]]