View source for 4nmi


==Crystal Structure of the Apo ectoine hydroxylase ECTD from Salibacillus salexigens==
<StructureSection load='4nmi' size='340' side='right'caption='[[4nmi]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4nmi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Virgibacillus_salexigens Virgibacillus salexigens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NMI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nmi OCA], [https://pdbe.org/4nmi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nmi RCSB], [https://www.ebi.ac.uk/pdbsum/4nmi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nmi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ECTD_VIRSA ECTD_VIRSA] Involved in the biosynthesis of ectoine ((S)-2-methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylic acid) which is a highly soluble organic osmolyte, called compatible solute, use to avoid excessive water efflux, plasmolysis, molecular crowding of the cytoplasm, and cessation of growth in high salinity environments. Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine.<ref>PMID:17636255</ref> 

==See Also==
*[[Hydroxylases 3D structures|Hydroxylases 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Virgibacillus salexigens]]
[[Category: Bremer E]]
[[Category: Hoeppner A]]
[[Category: Smits SH]]
[[Category: Widderich N]]