View source for 4p55


==Crystal structure of DNA binding domain of K11 from KSHV==
<StructureSection load='4p55' size='340' side='right'caption='[[4p55]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4p55]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_8_strain_GK18 Human herpesvirus 8 strain GK18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P55 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P55 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.504&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p55 OCA], [https://pdbe.org/4p55 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p55 RCSB], [https://www.ebi.ac.uk/pdbsum/4p55 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p55 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VIRF2_HHV8P VIRF2_HHV8P] Plays a role in the inhibition of host immune response. Acts by interacting with host EIF2AK2/PKR and inhibiting its activation. In turn, EIF2AK2/PKR substrates including EIF2S1 or histone H2A are not phosphorylated.<ref>PMID:11160738</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Human herpesvirus 8 strain GK18]]
[[Category: Large Structures]]
[[Category: Dong YH]]
[[Category: Gao ZQ]]
[[Category: Hu HD]]
[[Category: Lan K]]