View source for 4puf


==Complex between the Salmonella T3SS effector SlrP and its human target thioredoxin-1==
<StructureSection load='4puf' size='340' side='right'caption='[[4puf]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4puf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._14028S Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PUF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.296&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4puf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4puf OCA], [https://pdbe.org/4puf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4puf RCSB], [https://www.ebi.ac.uk/pdbsum/4puf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4puf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SLRP_SALT1 SLRP_SALT1] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (Thioredoxin). Leads to significant decrease of thioredoxin activity and increase of host cell death (By similarity).

==See Also==
*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]]
[[Category: Bernal-Bayard J]]
[[Category: Cardenal-Munoz E]]
[[Category: Cordero-Alba M]]
[[Category: Guimaraes B]]
[[Category: Lazar N]]
[[Category: Nessler S]]
[[Category: Ramos-Morales F]]
[[Category: Zouhir S]]