4puf

Complex between the Salmonella T3SS effector SlrP and its human target thioredoxin-1

spinqualitylabelsall models 4puf, resolution 3.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4puf is a 4 chain structure with sequence from Homo sapiens and Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.296Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function SLRP_SALT1 Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (Thioredoxin). Leads to significant decrease of thioredoxin activity and increase of host cell death (By similarity). See Also Thioredoxin 3D structures Ubiquitin protein ligase 3D structures

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