View source for 4qaf


==Crystal structure of an engineered lipocalin (Anticalin) in complex with VEGF(8-109)==
<StructureSection load='4qaf' size='340' side='right'caption='[[4qaf]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4qaf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QAF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QAF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=OMA:10-{(1R,2R)-2-[(2E)-HEX-2-EN-1-YL]CYCLOPROPYL}DECANOIC+ACID'>OMA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qaf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qaf OCA], [https://pdbe.org/4qaf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qaf RCSB], [https://www.ebi.ac.uk/pdbsum/4qaf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qaf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LCN1_HUMAN LCN1_HUMAN] Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket.

==See Also==
*[[Neutrophil gelatinase-associated lipocalin|Neutrophil gelatinase-associated lipocalin]]
*[[VEGF 3D Structures|VEGF 3D Structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Giese T]]
[[Category: Skerra A]]