View source for 4v88


==The structure of the eukaryotic ribosome at 3.0 A resolution.==
<StructureSection load='4v88' size='340' side='right'caption='[[4v88]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4v88]] is a 19 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V88 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=N:ANY+5-MONOPHOSPHATE+NUCLEOTIDE'>N</scene>, <scene name='pdbligand=OHX:OSMIUM+(III)+HEXAMMINE'>OHX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v88 OCA], [https://pdbe.org/4v88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v88 RCSB], [https://www.ebi.ac.uk/pdbsum/4v88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v88 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RS6A_YEAST RS6A_YEAST] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Ribosomes translate genetic information encoded by messenger RNA into proteins. Many aspects of translation and its regulation are specific to eukaryotes, whose ribosomes are much larger and intricate than their bacterial counterparts. We report the crystal structure of the 80S ribosome from the yeast Saccharomyces cerevisiae--including nearly all ribosomal RNA bases and protein side chains as well as an additional protein, Stm1--at a resolution of 3.0 angstroms. This atomic model reveals the architecture of eukaryote-specific elements and their interaction with the universally conserved core, and describes all eukaryote-specific bridges between the two ribosomal subunits. It forms the structural framework for the design and analysis of experiments that explore the eukaryotic translation apparatus and the evolutionary forces that shaped it.

The structure of the eukaryotic ribosome at 3.0 A resolution.,Ben-Shem A, Garreau de Loubresse N, Melnikov S, Jenner L, Yusupova G, Yusupov M Science. 2011 Dec 16;334(6062):1524-9. Epub 2011 Nov 17. PMID:22096102<ref>PMID:22096102</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4v88" style="background-color:#fffaf0;"></div>

==See Also==
*[[Ribosomal protein P0|Ribosomal protein P0]]
*[[Ribosomal protein P1|Ribosomal protein P1]]
*[[Ribosomal protein P2|Ribosomal protein P2]]
*[[Ribosomal protein S1|Ribosomal protein S1]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Ben-Shem A]]
[[Category: Garreau de Loubresse N]]
[[Category: Jenner L]]
[[Category: Melnikov S]]
[[Category: Yusupov M]]
[[Category: Yusupova G]]