View source for 4wfq


==Crystal structure of TFIIH subunit==
<StructureSection load='4wfq' size='340' side='right'caption='[[4wfq]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4wfq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WFQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WFQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wfq OCA], [https://pdbe.org/4wfq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wfq RCSB], [https://www.ebi.ac.uk/pdbsum/4wfq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wfq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SSL1_YEAST SSL1_YEAST] Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro. SSL1 is essential for translation initiation.<ref>PMID:7961739</ref> <ref>PMID:8631896</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Cho Y]]
[[Category: Kim JS]]
[[Category: Lim HS]]