View source for 4zyo


==Crystal Structure of Human Integral Membrane Stearoyl-CoA Desaturase with Substrate==
<StructureSection load='4zyo' size='340' side='right'caption='[[4zyo]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4zyo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZYO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=ST9:STEAROYL-COENZYME+A'>ST9</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zyo OCA], [https://pdbe.org/4zyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zyo RCSB], [https://www.ebi.ac.uk/pdbsum/4zyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zyo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SCD_HUMAN SCD_HUMAN] Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).[UniProtKB:P13516]<ref>PMID:15610069</ref> <ref>PMID:15907797</ref> <ref>PMID:18765284</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Klein MG]]
[[Category: Lane W]]
[[Category: Levin I]]
[[Category: Li K]]
[[Category: Sang B-C]]
[[Category: Snell G]]
[[Category: Wang H]]
[[Category: Zou H]]