View source for 5cnr


==Crystal structure-guided design of self-assembling RNA nano triangles==
<StructureSection load='5cnr' size='340' side='right'caption='[[5cnr]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5cnr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Senecavirus_A Senecavirus A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CNR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CNR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cnr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cnr OCA], [https://pdbe.org/5cnr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cnr RCSB], [https://www.ebi.ac.uk/pdbsum/5cnr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cnr ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
RNA nanotechnology uses RNA structural motifs to build nanosized architectures that assemble through selective base-pair interactions. Herein, we report the crystal-structure-guided design of highly stable RNA nanotriangles that self-assemble cooperatively from short oligonucleotides. The crystal structure of an 81 nucleotide nanotriangle determined at 2.6 A resolution reveals the so-far smallest circularly closed nanoobject made entirely of double-stranded RNA. The assembly of the nanotriangle architecture involved RNA corner motifs that were derived from ligand-responsive RNA switches, which offer the opportunity to control self-assembly and dissociation.

Crystal-Structure-Guided Design of Self-Assembling RNA Nanotriangles.,Boerneke MA, Dibrov SM, Hermann T Angew Chem Int Ed Engl. 2016 Feb 23. doi: 10.1002/anie.201600233. PMID:26914842<ref>PMID:26914842</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 5cnr" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Senecavirus A]]
[[Category: Boerneke M]]
[[Category: Dibrov S]]
[[Category: Hermann T]]