View source for 5dae


==Kazal type inhibitor from salivary glands of Aedes aegypti mosquito==
<StructureSection load='5dae' size='340' side='right'caption='[[5dae]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5dae]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DAE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DAE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dae OCA], [https://pdbe.org/5dae PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dae RCSB], [https://www.ebi.ac.uk/pdbsum/5dae PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dae ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q1HRB8_AEDAE Q1HRB8_AEDAE] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Blood-feeding exoparasites are rich sources of protease inhibitors, and the mosquito Aedes aegypti, which is a vector of Dengue virus, Yellow fever virus, Chikungunya virus and Zika virus, is no exception. AaTI is a single-domain, noncanonical Kazal-type serine proteinase inhibitor from A. aegypti that recognizes both digestive trypsin-like serine proteinases and the central protease in blood clotting, thrombin, albeit with an affinity that is three orders of magnitude lower. Here, the 1.4 A resolution crystal structure of AaTI is reported from extremely tightly packed crystals ( approximately 22% solvent content), revealing the structural determinants for the observed inhibitory profile of this molecule.

High-resolution structure of a Kazal-type serine protease inhibitor from the dengue vector Aedes aegypti.,Torquato RJS, Lu S, Martins NH, Tanaka AS, Pereira PJB Acta Crystallogr F Struct Biol Commun. 2017 Aug 1;73(Pt 8):469-475. doi:, 10.1107/S2053230X17010007. Epub 2017 Jul 26. PMID:28777090<ref>PMID:28777090</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5dae" style="background-color:#fffaf0;"></div>

==See Also==
*[[Trypsin inhibitor 3D structures|Trypsin inhibitor 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Aedes aegypti]]
[[Category: Large Structures]]
[[Category: Pereira PJB]]
[[Category: Tanaka AS]]
[[Category: Torquato RJS]]