View source for 5gpe


==Crystal structure of the transcription regulator PbrR691 from Ralstonia metallidurans CH34 in complex with Lead(II)==
<StructureSection load='5gpe' size='340' side='right'caption='[[5gpe]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5gpe]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Cupriavidus_metallidurans_CH34 Cupriavidus metallidurans CH34]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GPE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gpe OCA], [https://pdbe.org/5gpe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gpe RCSB], [https://www.ebi.ac.uk/pdbsum/5gpe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gpe ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q1LKZ5_CUPMC Q1LKZ5_CUPMC] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The transcription regulator PbrR691, one of the MerR family proteins, shows extremely high sensitivity and selectivity toward Pb(II) in Ralstonia metallidurans CH34. Here, we present the crystal structure of PbrR691 in complex with Pb(II) at 2.0 A resolution. The Pb(II) coordinates with three conserved cysteines and adopts a unique trigonal-pyramidal (hemidirected) geometry. To our knowledge, the PbrR691-Pb(II) structure provides the first three-dimensional visualization of a functional hemidirected lead(II) thiolate coordinate geometry in a protein.

Structural Basis for the Selective Pb(II) Recognition of Metalloregulatory Protein PbrR691.,Huang S, Liu X, Wang D, Chen W, Hu Q, Wei T, Zhou W, Gan J, Chen H Inorg Chem. 2016 Dec 19;55(24):12516-12519. Epub 2016 Nov 30. PMID:27989185<ref>PMID:27989185</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5gpe" style="background-color:#fffaf0;"></div>

==See Also==
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Cupriavidus metallidurans CH34]]
[[Category: Large Structures]]
[[Category: Chen H]]
[[Category: Chen WZ]]
[[Category: Gan JH]]
[[Category: Hu QY]]
[[Category: Huang SQ]]
[[Category: Liu XC]]
[[Category: Wang D]]