5gpe

Crystal structure of the transcription regulator PbrR691 from Ralstonia metallidurans CH34 in complex with Lead(II)

spinqualitylabelsall models 5gpe, resolution 2.01Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5gpe is a 8 chain structure with sequence from Cupriavidus metallidurans CH34. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.01Å Ligands: PB Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q1LKZ5_CUPMC Publication Abstract from PubMed The transcription regulator PbrR691, one of the MerR family proteins, shows extremely high sensitivity and selectivity toward Pb(II) in Ralstonia metallidurans CH34. Here, we present the crystal structure of PbrR691 in complex with Pb(II) at 2.0 A resolution. The Pb(II) coordinates with three conserved cysteines and adopts a unique trigonal-pyramidal (hemidirected) geometry. To our knowledge, the PbrR691-Pb(II) structure provides the first three-dimensional visualization of a functional hemidirected lead(II) thiolate coordinate geometry in a protein. Structural Basis for the Selective Pb(II) Recognition of Metalloregulatory Protein PbrR691.,Huang S, Liu X, Wang D, Chen W, Hu Q, Wei T, Zhou W, Gan J, Chen H Inorg Chem. 2016 Dec 19;55(24):12516-12519. Epub 2016 Nov 30. PMID:27989185 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Transcriptional activator 3D structures

Proteopedia Page Contributors and Editors (what is this?)

OCA