View source for 5hsm


==CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN RV2887==
<StructureSection load='5hsm' size='340' side='right'caption='[[5hsm]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5hsm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HSM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hsm OCA], [https://pdbe.org/5hsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hsm RCSB], [https://www.ebi.ac.uk/pdbsum/5hsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hsm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HTMR_MYCTU HTMR_MYCTU] Represses expression of the HQNO methyltransferase htm gene (Rv0560c) by binding to its promoter region (PubMed:26303802, PubMed:27432954, PubMed:28743871). Also represses the expression of at least five other genes, including the methyltransferase Rv0558 (PubMed:26303802). Binds salicylate (SA), para-aminosalicylic acid (PAS) and gemfibrozil (PubMed:28743871).<ref>PMID:26303802</ref> <ref>PMID:27432954</ref> <ref>PMID:28743871</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Bi LJ]]
[[Category: Gao YR]]
[[Category: Li DF]]
[[Category: Wang DC]]