View source for 5khs


==Crystal structures of the Burkholderia multivorans hopanoid transporter HpnN==
<StructureSection load='5khs' size='340' side='right'caption='[[5khs]], [[Resolution|resolution]] 3.76&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5khs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_multivorans Burkholderia multivorans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KHS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.758&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5khs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5khs OCA], [https://pdbe.org/5khs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5khs RCSB], [https://www.ebi.ac.uk/pdbsum/5khs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5khs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HPNN_BURM1 HPNN_BURM1] Essential for hopanoid transport from the cytoplasmic to the outer membrane (PubMed:28584102). Is capable of shuttling hopanoid lipids from the inner membrane to the periplasm, where they probably spontaneously insert to the inner leaflet of the outer membrane, strengthening the cell envelope (PubMed:28584102). May be a proton-motive-force (PMF)-dependent transporter (PubMed:28584102). Is critical for multidrug resistance and cell wall remodeling in Burkholderia (PubMed:28584102).<ref>PMID:28584102</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Burkholderia multivorans]]
[[Category: Large Structures]]
[[Category: Su C-C]]
[[Category: Yu EW]]