View source for 5kkx


==Crystal structure of a TbpB C-lobe mutant from Neisseria meningitidis M982==
<StructureSection load='5kkx' size='340' side='right'caption='[[5kkx]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5kkx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KKX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kkx OCA], [https://pdbe.org/5kkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kkx RCSB], [https://www.ebi.ac.uk/pdbsum/5kkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kkx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TBPB1_NEIMI TBPB1_NEIMI] Neisseria acquires iron by extracting it from serum transferrin (TF) in its human host. Acts as a TF receptor and is required for TF utilization. Involved in the initial capture of TF. Helps select only those TF molecules that can be used as an iron source and concentrates them on the cell surface, maintaining the iron-loaded status of the TF C-terminal lobe until its delivery to TbpA.<ref>PMID:22343719</ref> 

==See Also==
*[[Transferrin-binding protein|Transferrin-binding protein]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Neisseria meningitidis]]
[[Category: Calmettes C]]
[[Category: Moraes TF]]