View source for 5weg


==Crystal Structure of UDP-glucose pyrophosphorylase from Sugarcane==
<StructureSection load='5weg' size='340' side='right'caption='[[5weg]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5weg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharum_hybrid_cultivar_SP80-3280 Saccharum hybrid cultivar SP80-3280]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WEG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5weg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5weg OCA], [https://pdbe.org/5weg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5weg RCSB], [https://www.ebi.ac.uk/pdbsum/5weg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5weg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A075E2Q1_9POAL A0A075E2Q1_9POAL] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
UDP-glucose pyrophosphorylase (UGPase) is found in all organisms and catalyses the formation of UDP-glucose. In sugarcane, UDP-glucose is a branch-point in the carbon channelling into other carbohydrates, such as sucrose and cellulose, which are the major factors for sugarcane productivity. In most plants, UGPase has been described to be enzymatically active in the monomeric form, while in human and yeast, homo-octamers represent the active form of the protein. Here, we present the crystal structure of UGPase from sugarcane (ScUGPase-1) at resolution of 2.0 A. The crystals of ScUGPase-1 reveal the presence of two molecules in the asymmetric unit and the multi-angle light scattering analysis shows that ScUGPase-1 forms a mixture of species ranging from monomers to larger oligomers in solution, suggesting similarities with the orthologs from yeast and human.

Crystal structure and insights into the oligomeric state of UDP-glucose pyrophosphorylase from sugarcane.,Cotrim CA, Soares JSM, Kobe B, Menossi M PLoS One. 2018 Mar 1;13(3):e0193667. doi: 10.1371/journal.pone.0193667., eCollection 2018. PMID:29494650<ref>PMID:29494650</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5weg" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharum hybrid cultivar SP80-3280]]
[[Category: Cotrim CA]]
[[Category: Kobe B]]
[[Category: Menossi M]]
[[Category: Soares JSM]]