View source for 5xa6


==Ion channel modulation by scorpion haemolymph and its defensin ingredients uncovers origin of neurotoxins in telson formed in Paleozoic scorpion==
<StructureSection load='5xa6' size='340' side='right'caption='[[5xa6]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5xa6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buthus_sp._IY-2001 Buthus sp. IY-2001]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XA6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xa6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xa6 OCA], [https://pdbe.org/5xa6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xa6 RCSB], [https://www.ebi.ac.uk/pdbsum/5xa6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xa6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DEF3_MESMA DEF3_MESMA] Antibacterial peptide active against Gram-positive bacteria (including S.aureus ATCC25923 (MIC=2.5 uM), M.luteus AB93113 (MIC=2.5 uM), and the antibiotic-resistant S.epidermidis PRSE P1389 (MIC=1.25 uM)), but not against Gram-negative bacteria (including E.coli and P.aeruginosa) (PubMed:31954123). Also blocks the currents of Kv1.1/KCNA1 (57% inhibition), Kv1.2/KCNA2 (27.5% inhibition), Kv1.3/KCNA3 (IC(50)=23.4 nM, 84.3% inhibition), KCa3.1/KCNN4/IK (15% inhibition), KCa2.3/KCNN3/SK3 (87.5% inhibition) and Kv11.1/KCNH2/ERG1 (30.4% inhibition) channels (tested at 1 uM) (PubMed:31954123). It inhibits potassium channel current by interacting with the pore region (PubMed:31954123).<ref>PMID:31954123</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Buthus sp. IY-2001]]
[[Category: Large Structures]]
[[Category: Meng L]]
[[Category: Qu D]]
[[Category: Tian C]]
[[Category: Wu Y]]