View source for 5xeu


==crystal structure of Hcp2 from Salmonella typhimurium==
<StructureSection load='5xeu' size='340' side='right'caption='[[5xeu]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5xeu]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XEU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xeu OCA], [https://pdbe.org/5xeu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xeu RCSB], [https://www.ebi.ac.uk/pdbsum/5xeu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xeu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/H9L4J8_SALTM H9L4J8_SALTM] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
STM0279 is a putative cytoplasmic protein from Salmonella typhimurium and was recently renamed haemolysin co-regulated protein 2 (Hcp2), with the neighbouring STM0276 being Hcp1. Both of them are encoded by the type VI secretion system (T6SS) of the Salmonella pathogenicity island 6 (SPI-6) locus and have high sequence identity. The Hcp proteins may function as a vital component of the T6SS nanotube and as a transporter and chaperone of diverse effectors from the bacterial T6SS. In this study, the crystal structure and the oligomeric state in solution of Hcp2 from S. typhimurium (StHcp2) were investigated. The crystal structure refined to 3.0 A resolution showed that the protein is composed of a beta-barrel domain with extended loops and can form hexameric rings as observed in known Hcp homologues. Mutation of the extended loop was found to partly destabilize the hexameric conformation into monomers or cause the production of inclusion bodies, suggesting it has an important role in hexameric ring formation.

Crystal structure of the putative cytoplasmic protein STM0279 (Hcp2) from Salmonella typhimurium.,Lin QP, Gao ZQ, Geng Z, Zhang H, Dong YH Acta Crystallogr F Struct Biol Commun. 2017 Aug 1;73(Pt 8):463-468. doi:, 10.1107/S2053230X17010512. Epub 2017 Jul 26. PMID:28777089<ref>PMID:28777089</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5xeu" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
[[Category: Gao ZQ]]
[[Category: Lin QP]]
[[Category: Zhang H]]