View source for 5zc3


==The Crystal Structure of PcRxLR12==
<StructureSection load='5zc3' size='340' side='right'caption='[[5zc3]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5zc3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Phytophthora_capsici Phytophthora capsici]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZC3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.005&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zc3 OCA], [https://pdbe.org/5zc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zc3 RCSB], [https://www.ebi.ac.uk/pdbsum/5zc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zc3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A3F2YLV0_PHYCP A0A3F2YLV0_PHYCP] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
RxLR genes are a prominent class of effectors in oomycetes, and almost half of these proteins contain a conserved sequence motif termed the WY domain, that may exist singly, or as divergent tandem repeats in different effectors. Here we describe the crystal structure of PcRxLR12 (63-488) from Phytophthora capsici at 3.0A resolution. The structure consists of five tandemly arrayed WY-domains linked to each other by short connecting helices. Superposition of the WY-2 domain on the other four domains of PcRxLR12, show that the first alpha-helix termed the K motif, and Loop 3 which connects alpha3 and alpha4 are the key regions of structural divergence between the WY domains. A similar pattern was observed when WY-2 was superposed on the 11 WY domains from other oomycete effectors. We also note that an added connecting helix between WY domains in some RXLR effectors, ensures that the WY domains are oriented in the same direction.

Crystal structure of the RxLR effector PcRxLR12 from Phytophthora capsici.,Zhao L, Zhang X, Zhang X, Song W, Li X, Feng R, Yang C, Huang Z, Zhu C Biochem Biophys Res Commun. 2018 Aug 1. pii: S0006-291X(18)31623-1. doi:, 10.1016/j.bbrc.2018.07.121. PMID:30077372<ref>PMID:30077372</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5zc3" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Phytophthora capsici]]
[[Category: Zhang X]]
[[Category: Zhao L]]
[[Category: Zhu C]]