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==The postfusion structure of human-infecting Bourbon virus envelope glycoprotein==
<StructureSection load='5zkx' size='340' side='right'caption='[[5zkx]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5zkx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bourbon_virus Bourbon virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZKX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zkx OCA], [https://pdbe.org/5zkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zkx RCSB], [https://www.ebi.ac.uk/pdbsum/5zkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zkx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A140H4W8_9ORTO A0A140H4W8_9ORTO] 
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== Publication Abstract from PubMed ==
Thogotoviruses are important zoonotic viruses infecting a variety of domestic animals, as well as humans. Among these viruses, Bourbon virus (BRBV) is one of the several human-infecting members, which emerged in the US in recent years and caused human deaths. Here, we report the crystal structure of the BRBV envelope glycoprotein in the postfusion conformation. The structure adopts the typical fold of a class III viral fusion protein and displays an extensive positively charged electrostatic potential pattern, which resembles the glycoprotein of Dhori virus and is consistent with our previous predictions. In addition, compared to other previously defined class III viral fusion proteins, the structures of all thogotovirus glycoproteins and homologs are more similar to herpes virus glycoprotein Bs than to the rhabdovirus G proteins. Thus, class III viral fusion proteins are quite diverse in structure, and sub-classes may have developed during evolution.

Postfusion structure of human-infecting Bourbon virus envelope glycoprotein.,Bai C, Qi J, Wu Y, Wang X, Gao GF, Peng R, Gao F J Struct Biol. 2019 Nov 1;208(2):99-106. doi: 10.1016/j.jsb.2019.08.005. Epub, 2019 Aug 13. PMID:31419524<ref>PMID:31419524</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5zkx" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Bourbon virus]]
[[Category: Large Structures]]
[[Category: Gao F]]
[[Category: Peng RC]]
[[Category: Qi JX]]
[[Category: Wu Y]]