View source for 6alk


==NMR solution structure of the major beech pollen allergen Fag s 1==
<StructureSection load='6alk' size='340' side='right'caption='[[6alk]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6alk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fagus_sylvatica Fagus sylvatica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ALK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ALK FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6alk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6alk OCA], [https://pdbe.org/6alk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6alk RCSB], [https://www.ebi.ac.uk/pdbsum/6alk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6alk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/B7TWE6_FAGSY B7TWE6_FAGSY] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Fag s 1 is a member of the Pathogen Related protein family 10 (PR-10) and can elicit cross-reaction with IgE antibodies produced against the birch pollen allergen Bet v 1. The Nuclear Magnetic Resonance (NMR) structure of Fag s 1 is presented along with its dynamic properties. It shares 66% identity with Bet v 1 and exhibits the expected three alpha-helices and seven beta-sheets arranged as a semi-beta barrel and exposing the residues mapped as the Bet v 1 IgE epitope. The structural dynamics of Fag s 1 were monitored on the fast and intermediate timescales, using relaxation rates. The complex dynamics of Fag s 1 are closely related to the internal cavity, and they modulate IgE and ligand binding.

Structural basis for cross-reactivity and conformation fluctuation of the major beech pollen allergen Fag s 1.,Moraes AH, Asam C, Almeida FCL, Wallner M, Ferreira F, Valente AP Sci Rep. 2018 Jul 12;8(1):10512. doi: 10.1038/s41598-018-28358-1. PMID:30002383<ref>PMID:30002383</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6alk" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Fagus sylvatica]]
[[Category: Large Structures]]
[[Category: Almeida FCL]]
[[Category: Asam A]]
[[Category: Ferreira F]]
[[Category: Moraes AH]]
[[Category: Valente AP]]
[[Category: Wallner M]]