View source for 6azd


==Crystal structure of Physcomitrella patens KAI2-like H==
<StructureSection load='6azd' size='340' side='right'caption='[[6azd]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6azd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Physcomitrium_patens Physcomitrium patens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AZD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9701074&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6azd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6azd OCA], [https://pdbe.org/6azd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6azd RCSB], [https://www.ebi.ac.uk/pdbsum/6azd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6azd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A9SG07_PHYPA A9SG07_PHYPA] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
In plants, strigolactones are perceived by the dual receptor-hydrolase DWARF14 (D14). D14 belongs to the superfamily of alpha/beta hydrolases and is structurally similar to the karrikin receptor KARRIKIN INSENSITIVE 2 (KAI2). The moss Physcomitrella patens is an ideal model system for studying this receptor family, because it includes 11 highly related family members with unknown ligand specificity. We present the crystal structures of three Physcomitrella D14/KAI2-like proteins and describe a loop-based mechanism that leads to a permanent widening of the hydrophobic substrate gorge. We have identified protein clades that specifically perceive the karrikin KAR1 and the non-natural strigolactone isomer (-)-5-deoxystrigol in a highly stereoselective manner.

Structural Basis of Karrikin and Non-natural Strigolactone Perception in Physcomitrella patens.,Burger M, Mashiguchi K, Lee HJ, Nakano M, Takemoto K, Seto Y, Yamaguchi S, Chory J Cell Rep. 2019 Jan 22;26(4):855-865.e5. doi: 10.1016/j.celrep.2019.01.003. PMID:30673608<ref>PMID:30673608</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6azd" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Physcomitrium patens]]
[[Category: Burger M]]
[[Category: Chory J]]
[[Category: Lee HJ]]