View source for 6dte


==GlcNAc-inspired cyclophellitol bound to NagZ==
<StructureSection load='6dte' size='340' side='right'caption='[[6dte]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6dte]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_cenocepacia Burkholderia cenocepacia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DTE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DTE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.929&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H9J:2,2,2-tris(fluoranyl)-~{N}-[(2~{R},3~{R},5~{R},6~{R})-4-(hydroxymethyl)-2,3,5,6-tetrakis(oxidanyl)cyclohexyl]ethanamide'>H9J</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dte FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dte OCA], [https://pdbe.org/6dte PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dte RCSB], [https://www.ebi.ac.uk/pdbsum/6dte PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dte ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A125HFC0_9BURK A0A125HFC0_9BURK] Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.[HAMAP-Rule:MF_00364][SAAS:SAAS00634279]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The development of a potent mechanism-based inactivator of NagZ, an enzyme critical to the production of inducible AmpC beta-lactamase in Gram-negative bacteria, is presented. This inactivator significantly reduces MIC values for important beta-lactams against a clinically relevant strain of Pseudomonas aeruginosa.

A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to beta-lactams in Pseudomonas aeruginosa.,Ho LA, Winogrodzki JL, Debowski AW, Madden Z, Vocadlo DJ, Mark BL, Stubbs KA Chem Commun (Camb). 2018 Sep 25;54(75):10630-10633. doi: 10.1039/c8cc05281f. Epub, 2018 Sep 4. PMID:30178799<ref>PMID:30178799</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6dte" style="background-color:#fffaf0;"></div>

==See Also==
*[[Beta-Hexosaminidase|Beta-Hexosaminidase]]
*[[Beta-Hexosaminidase 3D structures|Beta-Hexosaminidase 3D structures]]
*[[Beta-N-acetylhexosaminidase 3D structures|Beta-N-acetylhexosaminidase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Burkholderia cenocepacia]]
[[Category: Large Structures]]
[[Category: Mark BL]]
[[Category: Winogrodzki JL]]