View source for 6dzm


==Bundibugyo virus GP (mucin-deleted) in complex with pan-ebolavirus human antibody ADI-15878 Fab==
<SX load='6dzm' size='340' side='right' viewer='molstar' caption='[[6dzm]], [[Resolution|resolution]] 4.29&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6dzm]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Bundibugyo_ebolavirus Bundibugyo ebolavirus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DZM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.29&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dzm OCA], [https://pdbe.org/6dzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dzm RCSB], [https://www.ebi.ac.uk/pdbsum/6dzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dzm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/B8XCN0_9MONO B8XCN0_9MONO] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Monoclonal antibodies (mAbs) with pan-ebolavirus cross-reactivity are highly desirable, but development of such mAbs is limited by a lack of a molecular understanding of cross-reactive epitopes. The antibody ADI-15878 was previously identified from a human survivor of Ebola virus Makona variant (EBOV/Mak) infection. This mAb demonstrated potent neutralizing activity against all known ebolaviruses and provided protection in rodent and ferret models against three ebolavirus species. Here, we describe the unliganded crystal structure of ADI-15878 as well as the cryo-EM structures of ADI-15878 in complex with the EBOV/Mak and Bundibugyo virus (BDBV) glycoproteins (GPs). ADI-15878 binds through an induced-fit mechanism by targeting highly conserved residues in the internal fusion loop (IFL), bridging across GP protomers via the heptad repeat 1 (HR1) region. Our structures provide a more complete description of the ebolavirus immunogenic landscape, as well as a molecular basis for how rare but potent antibodies target conserved filoviral fusion machinery.

Structural Basis of Pan-Ebolavirus Neutralization by an Antibody Targeting the Glycoprotein Fusion Loop.,Murin CD, Bruhn JF, Bornholdt ZA, Copps J, Stanfield R, Ward AB Cell Rep. 2018 Sep 4;24(10):2723-2732.e4. doi: 10.1016/j.celrep.2018.08.009. PMID:30184505<ref>PMID:30184505</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6dzm" style="background-color:#fffaf0;"></div>

==See Also==
*[[Glycoprotein GP 3D structures|Glycoprotein GP 3D structures]]
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
<references/>
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</SX>
[[Category: Bundibugyo ebolavirus]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Murin CD]]
[[Category: Ward AB]]