View source for 6k6u


==Crystal structure of the human YTHDC2 YTH domain==
<StructureSection load='6k6u' size='340' side='right'caption='[[6k6u]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6k6u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K6U FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k6u OCA], [https://pdbe.org/6k6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k6u RCSB], [https://www.ebi.ac.uk/pdbsum/6k6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k6u ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/YTDC2_HUMAN YTDC2_HUMAN] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
N(6)-methyladenosine (m(6)A) "readers" play an important role in mRNA functions and metabolism. YTHDC2, as one of the m(6)A readers, controls fertileness through decreasing associated mRNA abundance and enhancing the translation efficiency of related mRNA via binding the targeted m(6)A RNA. However, how YTH domain of YTHDC2 recognize m(6)A RNA is still unknown. In this study, we determined the crystal structure of human YTHDC2 YTH domain, which adopts similar architecture to other solved YTH domain structures. YTHDC2 contains a conserved m(6)A binding pocket, and similar RNA binding surface shared by YTHDC1.

Crystal structure of human YTHDC2 YTH domain.,Ma C, Liao S, Zhu Z Biochem Biophys Res Commun. 2019 Oct 22;518(4):678-684. doi:, 10.1016/j.bbrc.2019.08.107. Epub 2019 Aug 28. PMID:31472957<ref>PMID:31472957</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6k6u" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Liao S]]
[[Category: Ma C]]
[[Category: Xu C]]