View source for 6lus


==Crystal structure of the Mengla Virus VP30 C-terminal domain==
<StructureSection load='6lus' size='340' side='right'caption='[[6lus]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6lus]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mengla_dianlovirus Mengla dianlovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LUS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lus OCA], [https://pdbe.org/6lus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lus RCSB], [https://www.ebi.ac.uk/pdbsum/6lus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lus ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A3S8UVN5_9MONO A0A3S8UVN5_9MONO] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The family Filoviridae contains many important human viruses, including Marburg virus (MARV) and Ebola virus (EBOV). Mengla virus (MLAV), a newly discovered filovirus, is considered a potential human pathogen. The VP30 C-terminal domain (CTD) of these filoviruses plays an essential role in virion assembly. In common with other filoviruses, MLAV VP30 CTD mainly exists as a dimer in solution. In this work, we determined the crystal structure of recombinant MLAV VP30 CTD monomer, verifying that C-terminal helix-7 (H7) is critical for the dimerization process. This study provides a preliminary model for investigation of MLAV VP30 CTD as an anti-filovirus drug development target.

Crystal structure of the Mengla virus VP30 C-terminal domain.,Dong S, Wen K, Chu H, Li H, Yu Q, Wang C, Qin X Biochem Biophys Res Commun. 2020 Apr 30;525(2):392-397. doi: , 10.1016/j.bbrc.2020.02.089. Epub 2020 Feb 22. PMID:32093889<ref>PMID:32093889</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6lus" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mengla dianlovirus]]
[[Category: Chu HG]]
[[Category: Dong SS]]
[[Category: Qin XC]]
[[Category: Wang CH]]
[[Category: Wen KN]]