View source for 6mst


==Cryo-EM structure of human AA amyloid fibril==
<SX load='6mst' size='340' side='right' viewer='molstar' caption='[[6mst]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6mst]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MST OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MST FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mst OCA], [https://pdbe.org/6mst PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mst RCSB], [https://www.ebi.ac.uk/pdbsum/6mst PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mst ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN] Secondary amyloidosis. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.  Elevated serum SAA1 protein levels may be associated with lung cancer.
== Function ==
[https://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN] Major acute phase reactant. Apolipoprotein of the HDL complex.
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</SX>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fandrich M]]
[[Category: Grigorieff N]]
[[Category: Liberta F]]
[[Category: Loerch S]]
[[Category: Rennegarbe M]]
[[Category: Schmidt M]]