View source for 6nsj


==CryoEM structure of Helicobacter pylori urea channel in closed state==
<SX load='6nsj' size='340' side='right' viewer='molstar' caption='[[6nsj]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6nsj]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_J99 Helicobacter pylori J99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NSJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NSJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XP4:1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATE'>XP4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nsj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nsj OCA], [https://pdbe.org/6nsj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nsj RCSB], [https://www.ebi.ac.uk/pdbsum/6nsj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nsj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UREI_HELPJ UREI_HELPJ] Functions as a specific, H(+)-activated urea channel that increases the rate of urea entry into the cytoplasm, resulting in activation of cytoplasmic urease at acidic medium pH. Is essential for H.pylori gastric survival and colonization. Is necessary for the adaptation of urease activity to the extracellular pH, as in the presence of urea, UreI rapidly enhances the production of ammonia in the extracellular medium when the pH of the medium was decreased to pH5 or below (By similarity).

==See Also==
*[[Urease accessory protein 3D structures|Urease accessory protein 3D structures]]
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</SX>
[[Category: Helicobacter pylori J99]]
[[Category: Large Structures]]
[[Category: Cui YX]]
[[Category: Munson K]]
[[Category: Sachs G]]
[[Category: Strugatsky D]]
[[Category: Wen Y]]
[[Category: Zhou K]]
[[Category: Zhou ZH]]