View source for 6otb


==NMR structure of alpha conotoxin SII==
<StructureSection load='6otb' size='340' side='right'caption='[[6otb]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6otb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OTB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OTB FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6otb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6otb OCA], [https://pdbe.org/6otb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6otb RCSB], [https://www.ebi.ac.uk/pdbsum/6otb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6otb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAS2_CONST CAS2_CONST] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (PubMed:1390774). This toxin potently inhibits the rodent muscle nAChR (IC(50)=120 nM (adult subtype, alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE) and IC(50)=370 nM (fetal subtype, alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND)) and weakly inhibits neuronal nAChRs (PubMed:35357806). In contrast to alpha-conotoxins bearing 2 disulfide bonds (framework I), this conotoxin acts via a unique binding mode with the helix and the N- and C-termini buried in the binding pocket of muscle nAChRs (PubMed:35357806).<ref>PMID:1390774</ref> <ref>PMID:35357806</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Conus striatus]]
[[Category: Large Structures]]
[[Category: Alewood PF]]
[[Category: Chin YK-Y]]
[[Category: Wilhelm P]]