View source for 6tx1


==HPF1 from Nematostella vectensis==
<StructureSection load='6tx1' size='340' side='right'caption='[[6tx1]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6tx1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Nematostella_vectensis Nematostella vectensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TX1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.091&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tx1 OCA], [https://pdbe.org/6tx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tx1 RCSB], [https://www.ebi.ac.uk/pdbsum/6tx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tx1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HPF1_NEMVE HPF1_NEMVE] Cofactor for serine ADP-ribosylation that confers serine specificity on PARP. Switches the amino acid specificity of PARP from aspartate or glutamate to serine residues. Acts by completing the active site of PARP: forms a composite active site composed of residues from HPF1 and PARP.[UniProtKB:Q9NWY4]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Nematostella vectensis]]
[[Category: Ahel I]]
[[Category: Suskiewicz MJ]]