View source for 6tzn


==Structure of S. pombe telomerase accessory protein Pof8 C-terminal domain==
<StructureSection load='6tzn' size='340' side='right'caption='[[6tzn]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6tzn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TZN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tzn OCA], [https://pdbe.org/6tzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tzn RCSB], [https://www.ebi.ac.uk/pdbsum/6tzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tzn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/POF8_SCHPO POF8_SCHPO] RNA-binding protein required for assembly of the holoenzyme telomerase ribonucleoprotein (RNP) complex (PubMed:29422501, PubMed:29422503, PubMed:29422664). Specifically binds telomerase RNA ter1 and promotes assembly of ter1 with catalytic subunit trt1 (PubMed:29422501, PubMed:29422503). Telomerase is a ribonucleoprotein enzyme essential that copies new telomeric repeats onto chromosome ends and functions to maintain cell division (PubMed:29422501, PubMed:29422503, PubMed:29422664).<ref>PMID:29422501</ref> <ref>PMID:29422503</ref> <ref>PMID:29422664</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe 972h-]]
[[Category: Basu RS]]
[[Category: Cascio D]]
[[Category: Eichhorn CD]]
[[Category: Feigon J]]